ea0089b3 | Basic Science | NANETS2022
Pelle Eleonora
, Cives Mauro
, Medina Elliot
, Mason Charlotte C.
, Snedal Sebastian A.
, Bustos-Perez Xiomar E.
, Tordesillas Leticia
, Gomez Fontela Miguel
, Marques Rossetti Renata A.
, Maiorano Gabriele
, Luca Vince
, Hwu Patrick
, Abate-Daga Daniel
, Strosberg Jonathan
Background: Well-differentiated neuroendocrine tumors (NETs) are characterized by the overexpression of somatostatin receptors (SSTRs). To efficiently engage and activate tumor infiltrating lymphocytes against NET cells, we designed a novel bispecific T-cells engager (BiTE) composed of 2 molecules of somatostatin-14 (SST14), the hormone that physiologically binds SSTRs, linked with a single chain variable fragment (scFV)-based anti-CD3.Methods: The optim...